Ontology highlight
ABSTRACT:
SUBMITTER: Wu YC
PROVIDER: S-EPMC3401410 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wu Yen-Chi YC Chen Ching-Huan CH Mercer Adam A Sokol Nicholas S NS
Developmental cell 20120701 1
Many neural lineages display a temporal pattern, but the mechanisms controlling the ordered production of neuronal subtypes remain unclear. Here, we show that Drosophila let-7 and miR-125, cotranscribed from the let-7-Complex (let-7-C) locus, regulate the transcription factor chinmo to control temporal cell fate in the mushroom body (MB) lineage. We find that let-7-C is activated in postmitotic neurons born during the larval-to-pupal transition, when transitions among three MB subtypes occur. Lo ...[more]