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New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.


ABSTRACT: Through the use of a 1,2-metalate rearrangement, six 7-substituted farnesol analogs were generated in a concise manner. This new synthetic route allowed us to quickly prepare several diverse farnesyl diphosphate analogs with interesting biological activities against mammalian protein-farnesyl transferase.

SUBMITTER: Placzek AT 

PROVIDER: S-EPMC3401630 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.

Placzek Andrew T AT   Gibbs Richard A RA  

Organic letters 20110623 14


Through the use of a 1,2-metalate rearrangement, six 7-substituted farnesol analogs were generated in a concise manner. This new synthetic route allowed us to quickly prepare several diverse farnesyl diphosphate analogs with interesting biological activities against mammalian protein-farnesyl transferase. ...[more]

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