Ontology highlight
ABSTRACT:
SUBMITTER: Choi JN
PROVIDER: S-EPMC3402442 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Choi Jung Nam JN Kim Jeongmi J Kim Jiyoung J Jung Won Hee WH Lee Choong Hwan CH
PloS one 20120723 7
Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzymes of major metabolic pathways. Furthermore, iron plays a critical role in pathogen-host interactions. In this study, we analyzed metabolomic changes associated with iron availability and the iron regulatory protein Cir1 in a human fungal pathogen Cryptococcus neoformans. Our metabolite analysis revealed that Cir1 influences the glycolytic pathway, ergosterol biosynthesis and inositol metabolism, w ...[more]