Ontology highlight
ABSTRACT:
SUBMITTER: Jung WH
PROVIDER: S-EPMC1637126 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Jung Won Hee WH Sham Anita A White Rick R Kronstad James W JW
PLoS biology 20061101 12
Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus neoformans because the fungus senses iron to regulate elaboration of the polysaccharide capsule that is the major virulence factor during infection. Excess iron exacerbates experimental cryptococcosis and the prevalence of this disease in Sub-Saharan Africa has been associated with nutritional and genetic asp ...[more]