Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Danes A
PROVIDER: S-EPMC3403296 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Sánchez-Danés Adriana A Richaud-Patin Yvonne Y Carballo-Carbajal Iria I Jiménez-Delgado Senda S Caig Carles C Mora Sergio S Di Guglielmo Claudia C Ezquerra Mario M Patel Bindiben B Giralt Albert A Canals Josep M JM Memo Maurizio M Alberch Jordi J López-Barneo José J Vila Miquel M Cuervo Ana Maria AM Tolosa Eduard E Consiglio Antonella A Raya Angel A
EMBO molecular medicine 20120308 5
Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD). Here, we generated iPSC lines from seven patients with idiopathic PD (ID-PD), four patients with familial PD associated to the G2019S mutation in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene (LRRK2-PD) and four age- and sex-matched healthy individuals (Ctrl). Over lon ...[more]