Ontology highlight
ABSTRACT:
SUBMITTER: McFarland K
PROVIDER: S-EPMC3837375 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
McFarland Krista K Spalding Tracy A TA Hubbard David D Ma Jian-Nong JN Olsson Roger R Burstein Ethan S ES
ACS chemical neuroscience 20131011 11
Nurr1 is a nuclear hormone receptor (NucHR) strongly implicated in the growth, maintenance, and survival of dopaminergic neurons. Nurr1 may be unable to bind ligands directly, but it forms heterodimers with other NucHRs that do. Using bioluminescence resonance energy transfer (BRET) assays to directly monitor interactions of Nurr1 with other NucHRs, we found the cancer drug bexarotene (Targretin, also LGD1069) displayed biased interactions with Nurr1-RXR heterodimers compared with RXR-RXR homodi ...[more]