Mechanism of zinc-mediated inhibition of caspase-9.
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ABSTRACT:
SUBMITTER: Huber KL
PROVIDER: S-EPMC3403442 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Mechanism of zinc-mediated inhibition of caspase-9.
Huber Kristen L KL Hardy Jeanne A JA
Protein science : a publication of the Protein Society 20120524 7
Zinc-mediated inhibition is implicated in global caspase regulation, with relief of zinc-mediated inhibition central to both small-molecule and natively induced caspase activation. As an initiator, caspase-9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point. Here we identify two distinct zinc-binding sites on caspase-9. The first site, composed of H237, C239, and C287, includes the active site dyad and is primarily responsible for zinc-mediated in ...[more]
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