Ontology highlight
ABSTRACT:
SUBMITTER: Hessle V
PROVIDER: S-EPMC3404368 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Hessle Viktoria V von Euler Anne A González de Valdivia Ernesto E Visa Neus N
RNA (New York, N.Y.) 20120628 8
Rrp6 is an exoribonuclease involved in the quality control of mRNA biogenesis. We have analyzed the association of Rrp6 with the Balbiani ring pre-mRNPs of Chironomus tentans to obtain insight into the role of Rrp6 in splicing surveillance. Rrp6 is recruited to transcribed genes and its distribution along the genes does not correlate with the positions of exons and introns. In the nucleoplasm, Rrp6 is bound to both unspliced and spliced transcripts. Rrp6 is released from the mRNPs in the vicinit ...[more]