Ontology highlight
ABSTRACT:
SUBMITTER: Wilen CB
PROVIDER: S-EPMC3405824 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Wilen Craig B CB Tilton John C JC Doms Robert W RW
Cold Spring Harbor perspectives in medicine 20120801 8
The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system. HIV uses a complex series of steps to deliver its genome into the host cell cytoplasm while simultaneously evading the host immune response. To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequentia ...[more]