Ontology highlight
ABSTRACT:
SUBMITTER: Tsou LK
PROVIDER: S-EPMC3640310 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Bioorganic & medicinal chemistry letters 20120302 9
We report the mode of action of a proteomimetic compound that binds to the exterior surface of gp120 and blocks HIV-1 entry into cells. Using a one cycle time-of-addition study and antibody competition binding studies, we have determined that the compound blocks HIV-1 entry through modulation of key protein-protein interactions mediated by gp120. The compound exhibits anti-HIV-1 replication activities against several pseudotype viruses derived from primary isolates and the resistant strains isol ...[more]