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Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

ABSTRACT: We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

SUBMITTER: Sandor C

PROVIDER: S-EPMC3406008 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

Sandor Cynthia C Li Wanbo W Coppieters Wouter W Druet Tom T Charlier Carole C Georges Michel M

PLoS genetics 20120726 7

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot u ...[more]

PMID: 22844258

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