Ontology highlight
ABSTRACT:
SUBMITTER: Hanaoka M
PROVIDER: S-EPMC3406716 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120604 31
The circadian clock of cyanobacteria is composed of KaiA, KaiB, and KaiC proteins, and the SasA-RpaA two-component system has been implicated in the regulation of one of the output pathways of the clock. In this study, we show that another response regulator that is essential for viability, the RpaA paralog, RpaB, plays a central role in the transcriptional oscillation of clock-regulated genes. In vivo and in vitro analyses revealed that RpaB and not RpaA could specifically bind to the kaiBC pro ...[more]