Ontology highlight
ABSTRACT:
SUBMITTER: Sharma S
PROVIDER: S-EPMC3407949 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Sharma Salil S Liu Jing J Wei Jianqin J Yuan Huijun H Zhang Taifang T Bishopric Nanette H NH
EMBO molecular medicine 20120424 7
An increase in cardiac workload, ultimately resulting in hypertrophy, generates oxidative stress and therefore requires the activation of both survival and growth signal pathways. Here, we wanted to characterize the regulators, targets and mechanistic roles of miR-142, a microRNA (miRNA) negatively regulated during hypertrophy. We show that both miRNA-142-3p and -5p are repressed by serum-derived growth factors in cultured cardiac myocytes, in models of cardiac hypertrophy in vivo and in human c ...[more]