Ontology highlight
ABSTRACT:
SUBMITTER: Rankin EB
PROVIDER: S-EPMC3408231 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Rankin Erinn B EB Wu Colleen C Khatri Richa R Wilson Tremika L S TL Andersen Rebecca R Araldi Elisa E Rankin Andrew L AL Yuan Jenny J Kuo Calvin J CJ Schipani Ernestina E Giaccia Amato J AJ
Cell 20120301 1
Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain unknown. We show that augmented HIF signaling in osteoprogenitors results in HSC niche expansion associated with selective expansion of the erythroid lineage. Increased red blood cell production occurred in an EPO-dependent manner with increased EPO expression in bone and suppressed EPO expression in the kidney. In contrast, inactivation ...[more]