Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC3408737 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kim Hyangin H Chen Lucy L Lim Grewo G Sung Backil B Wang Shuxing S McCabe Michael F MF Rusanescu Gabriel G Yang Liling L Tian Yinghong Y Mao Jianren J
The Journal of clinical investigation 20120702 8
Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity. We found that chronic pain in rats induced depressive behavior and IDO1 upregulation in the bilateral hippocampus. Upregulation of IDO1 resulted in the increased kynurenine/tryptophan ratio and decreased serotonin/tryptophan ratio in t ...[more]