Ontology highlight
ABSTRACT:
SUBMITTER: Lee RS
PROVIDER: S-EPMC3408754 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Lee Ryan S RS Stewart Chip C Carter Scott L SL Ambrogio Lauren L Cibulskis Kristian K Sougnez Carrie C Lawrence Michael S MS Auclair Daniel D Mora Jaume J Golub Todd R TR Biegel Jaclyn A JA Getz Gad G Roberts Charles W M CW
The Journal of clinical investigation 20120717 8
Cancer is principally considered a genetic disease, and numerous mutations are thought essential to drive its growth. However, the existence of genomically stable cancers and the emergence of mutations in genes that encode chromatin remodelers raise the possibility that perturbation of chromatin structure and epigenetic regulation are capable of driving cancer formation. Here we sequenced the exomes of 35 rhabdoid tumors, highly aggressive cancers of early childhood characterized by biallelic lo ...[more]