Ontology highlight
ABSTRACT:
SUBMITTER: Chun HE
PROVIDER: S-EPMC5094835 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Chun Hye-Jung E HE Lim Emilia L EL Heravi-Moussavi Alireza A Saberi Saeed S Mungall Karen L KL Bilenky Mikhail M Carles Annaick A Tse Kane K Shlafman Inna I Zhu Kelsey K Qian Jenny Q JQ Palmquist Diana L DL He An A Long William W Goya Rodrigo R Ng Michelle M LeBlanc Veronique G VG Pleasance Erin E Thiessen Nina N Wong Tina T Chuah Eric E Zhao Yong-Jun YJ Schein Jacquie E JE Gerhard Daniela S DS Taylor Michael D MD Mungall Andrew J AJ Moore Richard A RA Ma Yussanne Y Jones Steven J M SJM Perlman Elizabeth J EJ Hirst Martin M Marra Marco A MA
Cancer cell 20160301 3
Malignant rhabdoid tumors (MRTs) are rare lethal tumors of childhood that most commonly occur in the kidney and brain. MRTs are driven by SMARCB1 loss, but the molecular consequences of SMARCB1 loss in extra-cranial tumors have not been comprehensively described and genomic resources for analyses of extra-cranial MRT are limited. To provide such data, we used whole-genome sequencing, whole-genome bisulfite sequencing, whole transcriptome (RNA-seq) and microRNA sequencing (miRNA-seq), and histone ...[more]