Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3408839 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Zhang Haojian H Peng Cong C Hu Yiguo Y Li Huawei H Sheng Zhi Z Chen Yaoyu Y Sullivan Con C Cerny Jan J Hutchinson Lloyd L Higgins Anne A Miron Patricia P Zhang Xueqing X Brehm Michael A MA Li Dongguang D Green Michael R MR Li Shaoguang S
Nature genetics 20120715 8
A therapeutic strategy for treating cancer is to target and eradicate cancer stem cells (CSCs) without harming their normal stem cell counterparts. The success of this approach relies on the identification of molecular pathways that selectively regulate CSC function. Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for CSCs, we show that BCR-ABL downregulates the Blk gene (encoding B-lymphoid kinase) through c-Myc in leukemic stem cells (LSCs) in CML mice and that Blk func ...[more]