Ontology highlight
ABSTRACT:
SUBMITTER: Tusa I
PROVIDER: S-EPMC6178886 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Tusa Ignazia I Cheloni Giulia G Poteti Martina M Gozzini Antonella A DeSouza Ngoc Ho NH Shan Yi Y Deng Xianming X Gray Nathanael S NS Li Shaoguang S Rovida Elisabetta E Dello Sbarba Persio P
Stem cell reports 20180920 4
Tyrosine kinase inhibitors (TKi) are effective against chronic myeloid leukemia (CML), but their inefficacy on leukemia stem cells (LSCs) may lead to relapse. To identify new druggable targets alternative to BCR/ABL, we investigated the role of the MEK5/ERK5 pathway in LSC maintenance in low oxygen, a feature of bone marrow stem cell niches. We found that MEK5/ERK5 pathway inhibition reduced the growth of CML patient-derived cells and cell lines in vitro and the number of leukemic cells in vivo. ...[more]