Ontology highlight
ABSTRACT:
SUBMITTER: Naidu SR
PROVIDER: S-EPMC3409012 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Naidu Samisubbu R SR Lakhter Alexander J AJ Androphy Elliot J EJ
Cell cycle (Georgetown, Tex.) 20120715 14
Posttranslational modifications of p53 integrate diverse stress signals and regulate its activity, but their combinatorial contribution to overall p53 function is not clear. We investigated the roles of lysine (K) acetylation and sumoylation on p53 and their relation to apoptosis and autophagy. Here we describe the collaborative role of the SUMO E3 ligase PIASy and the lysine acetyltransferase Tip60 in p53-mediated autophagy. PIASy binding to p53 and PIASy-activated Tip60 lead to K386 sumoylatio ...[more]