Ontology highlight
ABSTRACT:
SUBMITTER: Jayanthi S
PROVIDER: S-EPMC3409220 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Jayanthi Shridhar S Del Vecchio Domitilla D
PloS one 20120731 7
Periodic oscillations play a key role in cell physiology from the cell cycle to circadian clocks. The interplay of positive and negative feedback loops among genes and proteins is ubiquitous in these networks. Often, delays in a negative feedback loop and/or degradation rates are a crucial mechanism to obtain sustained oscillations. How does nature control delays and kinetic rates in feedback networks? Known mechanisms include proper selection of the number of steps composing a feedback loop and ...[more]