Ontology highlight
ABSTRACT:
SUBMITTER: Bosch M
PROVIDER: S-EPMC3409647 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Bosch Marta M Marí Montserrat M Herms Albert A Fernández Ana A Fajardo Alba A Kassan Adam A Giralt Albert A Colell Anna A Balgoma David D Barbero Elisabet E González-Moreno Elena E Matias Nuria N Tebar Francesc F Balsinde Jesús J Camps Marta M Enrich Carlos C Gross Steven P SP García-Ruiz Carmen C Pérez-Navarro Esther E Fernández-Checa José C JC Pol Albert A
Current biology : CB 20110414 8
Caveolins (CAVs) are essential components of caveolae, plasma membrane invaginations with reduced fluidity, reflecting cholesterol accumulation. CAV proteins bind cholesterol, and CAV's ability to move between cellular compartments helps control intracellular cholesterol fluxes. In humans, CAV1 mutations result in lipodystrophy, cell transformation, and cancer. CAV1 gene-disrupted mice exhibit cardiovascular diseases, diabetes, cancer, atherosclerosis, and pulmonary fibrosis. The mechanism or me ...[more]