Ontology highlight
ABSTRACT:
SUBMITTER: West AP
PROVIDER: S-EPMC3409792 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
West Anthony P AP Diskin Ron R Nussenzweig Michel C MC Bjorkman Pamela J PJ
Proceedings of the National Academy of Sciences of the United States of America 20120627 30
A large number of anti-HIV-1 antibodies targeting the CD4-binding site (CD4bs) on the envelope glycoprotein gp120 have recently been reported. These antibodies, typified by VRC01, are remarkable for both their breadth and their potency. Crystal structures have revealed a common mode of binding for several of these antibodies; however, the precise relationship among CD4bs antibodies remains to be defined. Here we analyze existing structural and sequence data, propose a set of signature features f ...[more]