Ontology highlight
ABSTRACT:
SUBMITTER: Gupta P
PROVIDER: S-EPMC3410444 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Gupta Prasoon P Sharma Upasana U Schulz Thomas C TC Sherrer Eric S ES McLean Amanda B AB Robins Allan J AJ West Lyndon M LM
Organic letters 20110712 15
Three new briarane diterpenoids, briareolate esters L-N (1-3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a "spring-loaded" (E,Z)-dieneone Michael acceptor group that can form a rev ...[more]