Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya K
PROVIDER: S-EPMC3410530 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Bhattacharya Kanishka K McCarthy Mark I MI Morris Andrew P AP
Genetic epidemiology 20110921 8
Genome-wide association (GWA) studies have been extremely successful in identifying novel loci contributing effects to a wide range of complex human traits. However, despite this success, the joint marginal effects of these loci account for only a small proportion of the heritability of these traits. Interactions between variants in different loci are not typically modelled in traditional GWA analysis, but may account for some of the missing heritability in humans, as they do in other model orga ...[more]