Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura Y
PROVIDER: S-EPMC3411177 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Immunity 20120719 1
Cryopyrin-associated periodic syndromes (CAPS) are caused by aberrant interleukin-1β (IL-1β) production induced by mutations in the NLRP3 protein in humans, but the mechanisms involved remain poorly understood. Using a mouse model, we show a role for the indigenous microbiota and mast cells (MCs) in skin disease associated with mutant Nlrp3 protein. Unlike normal cells, MCs expressing mutant Nlrp3 produced IL-1β in response to lipopolysaccharide or tumor necrosis factor-α (TNF-α). In neonatal mi ...[more]