Ontology highlight
ABSTRACT:
SUBMITTER: Correa VSMC
PROVIDER: S-EPMC9989921 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Correa Victor S M C VSMC Efstathiou Nikolaos E NE Ntentakis Dimitrios P DP Yu Zhen Z Narimatsu Toshio T Gragoudas Evangelos E Kim Ivana K IK Vavvas Demetrios G DG
FEBS open bio 20230212 3
Uveal melanoma (UM) is the most common primary intraocular cancer in the adult population. Recent studies suggested that the NLRP3 inflammasome could be a therapeutic target for cutaneous melanoma (CM), but the role of NLRP3 in UM remains unknown. Here, we analyzed the NLRP3-IL-1β axis in 5 UM and 4 CM cell lines. Expression of NLRP3 mRNA in UM and CM was low, and expression in UM was lower than in CM (P < 0.001). NLRP3 protein levels were below detection limit for all cell lines. UM exhibited l ...[more]