Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3411617 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Li Yuqing Y Low Hui-Qi HQ Foo Jia Nee JN Darabi Hatef H Einarsdόttir Kristjana K Humphreys Keith K Spurdle Amanda A Easton Douglas F DF Thompson Deborah J DJ Dunning Alison M AM Pharoah Paul D P PD Czene Kamila K Chia Kee Seng KS Hall Per P Liu Jianjun J
PloS one 20120802 8
Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER cofactor genes may alter cellular response to estrogen exposure and consequently modify the risk for endometrial cancer. We genotyped 685 tagging SNPs within 60 ER cofactor genes in 564 endometrial cancer cases and 1,510 controls from Sweden, and tested their associations with the risk of endometrial cancer. We investigated the associations of in ...[more]