Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
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ABSTRACT:
SUBMITTER: Holm CK
PROVIDER: S-EPMC3411909 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm Christian K CK Jensen Søren B SB Jakobsen Martin R MR Cheshenko Natalia N Horan Kristy A KA Moeller Hanne B HB Gonzalez-Dosal Regina R Rasmussen Simon B SB Christensen Maria H MH Yarovinsky Timur O TO Rixon Frazer J FJ Herold Betsy C BC Fitzgerald Katherine A KA Paludan Søren R SR
Nature immunology 20120617 8
The innate immune system senses infection by detecting either evolutionarily conserved molecules essential for the survival of microbes or the abnormal location of molecules. Here we demonstrate the existence of a previously unknown innate detection mechanism induced by fusion between viral envelopes and target cells. Virus-cell fusion specifically stimulated a type I interferon response with expression of interferon-stimulated genes, in vivo recruitment of leukocytes and potentiation of signali ...[more]
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