Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5026396 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Wang Xin X Majumdar Tanmay T Kessler Patricia P Ozhegov Evgeny E Zhang Ying Y Chattopadhyay Saurabh S Barik Sailen S Sen Ganes C GC
Cell host & microbe 20160901 3
The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here, we report an essential role for TRIF in STING signaling: various activators of STING could not induce genes in the absence of TRIF. TRIF and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling. H ...[more]