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Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.

ABSTRACT: The adult central nervous system (CNS) has a remarkable ability to repair itself. However, severe brain and spinal cord injuries (SCIs) cause lasting disability and there are only a few therapies that can prevent or restore function in such cases. In this review, we provide an overview of traumatic CNS injuries and discuss several emerging pharmacological options that have shown promise in preclinical and early clinical studies. We highlight therapies that modulate mammalian target of rapamycin (mTOR) signaling, a pathway that is well known for its roles in cell growth, metabolism and cancer. Interestingly, this pathway is also gaining newfound attention for its role in CNS repair and regeneration.

SUBMITTER: Don AS

PROVIDER: S-EPMC3411916 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.

Don Aruni S Arachchige AS Tsang Chi Kwan CK Kazdoba Tatiana M TM D'Arcangelo Gabriella G Young Wise W Zheng X F Steven XF

Drug discovery today 20120427 15-16

The adult central nervous system (CNS) has a remarkable ability to repair itself. However, severe brain and spinal cord injuries (SCIs) cause lasting disability and there are only a few therapies that can prevent or restore function in such cases. In this review, we provide an overview of traumatic CNS injuries and discuss several emerging pharmacological options that have shown promise in preclinical and early clinical studies. We highlight therapies that modulate mammalian target of rapamycin ...[more]

PMID: 22569182

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