Ontology highlight
ABSTRACT:
SUBMITTER: Lim J
PROVIDER: S-EPMC3412482 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Lim Junghee J Kim Jungeun J Duong Tam T Lee Guewha G Kim Junghee J Yoon Jina J Kim Jaetaek J Kim Hyuncheol H Ruley H Earl HE El-Rifai Wael W Jo Daewoong D
Molecular therapy : the journal of the American Society of Gene Therapy 20120522 8
Practical methods to deliver proteins systemically in animals have been hampered by poor tissue penetration and inefficient cytoplasmic localization of internalized proteins. We therefore pursued the development of improved macromolecule transduction domains (MTDs) and tested their ability to deliver therapeutically active p18(INK4c). MTD103 was identified from a screen of 1,500 signal peptides; tested for the ability to promote protein uptake by cells and tissues; and analyzed with regard to th ...[more]