Ontology highlight
ABSTRACT:
SUBMITTER: Solomon DA
PROVIDER: S-EPMC4394609 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Solomon David A DA Kim Jung-Sik JS Jenkins Sultan S Ressom Habtom H Huang Michael M Coppa Nicholas N Mabanta Lauren L Bigner Darell D Yan Hai H Jean Walter W Waldman Todd T
Cancer research 20080401 8
Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of glioblastoma multiforme (GBM), these alterations are most commonly due to homozygous deletion of p16(INK4a) and less commonly due to genomic amplifications of individual genes encoding cyclins or cdks. Here, we describe deletion of the p18(INK4c) cdk inhibitor as a novel genetic alteration driving the pathogenesis of GBM. Del ...[more]