Ontology highlight
ABSTRACT:
SUBMITTER: Mariani J
PROVIDER: S-EPMC3413107 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Mariani J J Favaro R R Lancini C C Vaccari G G Ferri A L AL Bertolini J J Tonoli D D Latorre E E Caccia R R Ronchi A A Ottolenghi S S Miyagi S S Okuda A A Zappavigna V V Nicolis S K SK
Nucleic acids research 20120411 14
The transcription factor Sox2 is essential for neural stem cells (NSC) maintenance in the hippocampus and in vitro. The transcription factor Emx2 is also critical for hippocampal development and NSC self-renewal. Searching for 'modifier' genes affecting the Sox2 deficiency phenotype in mouse, we observed that loss of one Emx2 allele substantially increased the telencephalic β-geo (LacZ) expression of a transgene driven by the 5' or 3' Sox2 enhancer. Reciprocally, Emx2 overexpression in NSC cultu ...[more]