Ontology highlight
ABSTRACT:
SUBMITTER: Minguillon C
PROVIDER: S-EPMC3413163 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Minguillon Carolina C Nishimoto Satoko S Wood Sophie S Vendrell Elisenda E Gibson-Brown Jeremy J JJ Logan Malcolm P O MP
Development (Cambridge, England) 20120901 17
Tbx4 and Tbx5 are two closely related T-box genes that encode transcription factors expressed in the prospective hindlimb and forelimb territories, respectively, of all jawed vertebrates. Despite their striking limb type-restricted expression pattern, we have shown that these genes do not participate in the acquisition of limb type-specific morphologies. Instead, Tbx4 and Tbx5 play similar roles in the initiation of hindlimb and forelimb outgrowth, respectively. We hypothesized that different co ...[more]