Ontology highlight
ABSTRACT:
SUBMITTER: Cunningham TJ
PROVIDER: S-EPMC6034701 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cunningham Thomas J TJ Lancman Joseph J JJ Berenguer Marie M Dong P Duc Si PDS Duester Gregg G
Cell reports 20180601 11
A standard approach in the identification of transcriptional enhancers is the use of transgenic animals carrying DNA elements joined to reporter genes inserted randomly in the genome. We examined elements near Tbx5, a gene required for forelimb development in humans and other vertebrates. Previous transgenic studies reported a mammalian Tbx5 forelimb enhancer located in intron 2 containing a putative retinoic acid response element and a zebrafish tbx5a forelimb (pectoral fin) enhancer located do ...[more]