Ontology highlight
ABSTRACT:
SUBMITTER: Bellis J
PROVIDER: S-EPMC3413367 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
The Journal of cell biology 20120730 3
The stem cells (SCs) at the bottom of intestinal crypts tightly contact niche-supporting cells and fuel the extraordinary tissue renewal of intestinal epithelia. Their fate is regulated stochastically by populational asymmetry, yet whether asymmetrical fate as a mode of SC division is relevant and whether the SC niche contains committed progenitors of the specialized cell types are under debate. We demonstrate spindle alignments and planar cell polarities, which form a novel functional unit that ...[more]