Ontology highlight
ABSTRACT:
SUBMITTER: Lapierre M
PROVIDER: S-EPMC4001527 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Lapierre Marion M Bonnet Sandrine S Bascoul-Mollevi Caroline C Ait-Arsa Imade I Jalaguier Stéphan S Del Rio Maguy M Plateroti Michela M Roepman Paul P Ychou Marc M Pannequin Julie J Hollande Frédéric F Parker Malcolm M Cavailles Vincent V
The Journal of clinical investigation 20140325 5
Deregulation of the Wnt/APC/β-catenin signaling pathway is an important consequence of tumor suppressor APC dysfunction. Genetic and molecular data have established that disruption of this pathway contributes to the development of colorectal cancer. Here, we demonstrate that the transcriptional coregulator RIP140 regulates intestinal homeostasis and tumorigenesis. Using Rip140-null mice and mice overexpressing human RIP140, we found that RIP140 inhibited intestinal epithelial cell proliferation ...[more]