AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
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ABSTRACT:
SUBMITTER: Cunningham KA
PROVIDER: S-EPMC3413480 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Cunningham Katherine A KA Hua Zhaolin Z Srinivasan Supriya S Liu Jason J Lee Brian H BH Edwards Robert H RH Ashrafi Kaveh K
Cell metabolism 20120701 1
Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcr ...[more]
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