AMP-Activated Protein Kinase and Host Defense against Infection.
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ABSTRACT:
SUBMITTER: Silwal P
PROVIDER: S-EPMC6274990 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
AMP-Activated Protein Kinase and Host Defense against Infection.
Silwal Prashanta P Kim Jin Kyung JK Yuk Jae-Min JM Jo Eun-Kyeong EK
International journal of molecular sciences 20181106 11
5'-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrim ...[more]
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