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Impact of Tat Genetic Variation on HIV-1 Disease.

ABSTRACT: The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.

SUBMITTER: Li L

PROVIDER: S-EPMC3414192 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Impact of Tat Genetic Variation on HIV-1 Disease.

Li Luna L Dahiya Satinder S Kortagere Sandhya S Aiamkitsumrit Benjamas B Cunningham David D Pirrone Vanessa V Nonnemacher Michael R MR Wigdahl Brian B

Advances in virology 20120730

The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within tat of different HIV-1 subtypes has been sh ...[more]

PMID: 22899925

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