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Asexuals, polyploids, evolutionary opportunists...: the population genetics of positive but deteriorating mutations.


ABSTRACT: Some genetic phenomena originate as mutations that are initially advantageous but decline in fitness until they become distinctly deleterious. Here I give the condition for a mutation-selection balance to form and describe some of the properties of the resulting equilibrium population. A characterization is also given of the fixation probabilities for such mutations.

SUBMITTER: Bengtsson BO 

PROVIDER: S-EPMC3416017 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Asexuals, polyploids, evolutionary opportunists...: the population genetics of positive but deteriorating mutations.

Bengtsson Bengt O BO  

Genetics 20120517 4


Some genetic phenomena originate as mutations that are initially advantageous but decline in fitness until they become distinctly deleterious. Here I give the condition for a mutation-selection balance to form and describe some of the properties of the resulting equilibrium population. A characterization is also given of the fixation probabilities for such mutations. ...[more]

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