Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.
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ABSTRACT:
SUBMITTER: Lewis MJ
PROVIDER: S-EPMC3416319 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.
Lewis Martha J MJ Dagarag Mirabelle M Khan Basim B Ali Ayub A Yang Otto O OO
Journal of virology 20120502 13
Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete e ...[more]
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