Ontology highlight
ABSTRACT:
SUBMITTER: Iwata A
PROVIDER: S-EPMC3416413 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Iwata Atsushi A Alshahni Mohamed Mahdi MM Nishiyama Yayoi Y Makimura Koichi K Abe Shigeru S Yamada Tsuyoshi T
Applied and environmental microbiology 20120518 15
Targeted gene deletion is now available for molecular genetic research of dermatophytes, and the physiological roles of several genes have been elucidated. However, this method cannot be applied to essential genes, which can be potential drug targets. To overcome this limitation, we have developed a conditional gene knockdown system using a copper-responsive promoter. The promoter sequence of the copper transporter gene CTR4 (P(CTR4)) and that of the copper efflux pump gene CRP1 (P(CRP1)) derive ...[more]