Glutathione S-transferase M1 gene polymorphism and laryngeal cancer risk: a meta-analysis.

ABSTRACT:

Background and objectives

Studies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk.

Methods

The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until May 2011 and selected on the basis of the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize association of GSTM1 polymorphism with laryngeal cancer susceptibility.

Results

Seventeen studies were included in the present meta-analysis (2,180 cases and 2,868 controls). The combined results based on all studies showed that GSTM1 null genotype was associated with increased laryngeal cancer risk (OR?=?1.17, 95% CI?=?1.04?1.31). When stratifying for race, GSTM1 null genotype exhibited increased laryngeal cancer risk in Caucasians (OR?=?1.15, 95% CI?=?1.01?1.31), while no significant association was detected in Asians (OR?=?1.25, 95% CI?=?0.80?1.96). In the subgroup analysis based on source of controls, significant associations were observed in the population-based studies (OR?=?1.15, 95% CI?=?1.01?1.31) yet not in the hospital-based studies (OR?=?1.25, 95% CI?=?0.93?1.67). Furthermore, in the subgroup analysis based on sample size, significant associations were also found in studies with at least 50 cases and 50 controls (OR?=?1.15, 95% CI?=?1.02?1.30) but not in studies with fewer than 50 cases or 50 controls (OR?=?1.46, 95% CI?=?0.87?2.46).

Conclusions

This meta-analysis supported that the GSTM1 gene polymorphism was associated with laryngeal cancer, particularly in Caucasians, and these associations varied in different subgroup, which indicated that population-based study with larger sample size was more appropriate in design of future study.

SUBMITTER: Ying XJ 

PROVIDER: S-EPMC3416752 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature