Dataset Information

Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.

ABSTRACT:

Background

Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible associations of the GSTM1 and GSTT1 null genotype in cancer risks.

Methods

A meta-analysis based on 506 case-control studies was performed. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association.

Results

The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk in cancer (for GSTM1: OR?=?1.17; 95%CI?=?1.14-1.21; for GSTT1: OR?=?1.16; 95%CI?=?1.11-1.21, respectively). When the analysis was performed based on their smoking history, the risk associated of GSTM1 null and GSTT1 null genotypes with cancer is further increased (for GSTM1: OR?=?2.66; 95%CI?=?2.19-3.24; for GSTT1: OR?=?2.46; 95%CI?=?1.83-3.32, respectively).

Conclusions

These findings indicate that GSTM1 and GSTT1 polymorphisms may play critical roles in the development of cancer, especially in smokers.

SUBMITTER: Fang J

PROVIDER: S-EPMC3826727 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.

Fang Jianzheng J Wang Shangqian S Zhang Shengli S Su Shifeng S Song Zhen Z Deng Yunfei Y Cui Hongqing H Wang Hainan H Zhang Yi Y Qian Jian J Gu Jinbao J Liu Bianjiang B Li Pengchao P Zhang Rui R Liu Xinnong X Wang Zengjun Z

PloS one 20131108 11

<h4>Background</h4>Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible associations of the GSTM1 and GSTT1 null genotype in cancer risks.<h4>Methods</h4>A meta-analysis based on 506 case-control studies ...[more]

PMID: 24250808

Similar Datasets

Project description:Background and objectivesStudies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk.MethodsThe relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until May 2011 and selected on the basis of the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize association of GSTM1 polymorphism with laryngeal cancer susceptibility.ResultsSeventeen studies were included in the present meta-analysis (2,180 cases and 2,868 controls). The combined results based on all studies showed that GSTM1 null genotype was associated with increased laryngeal cancer risk (OR = 1.17, 95% CI = 1.04∼1.31). When stratifying for race, GSTM1 null genotype exhibited increased laryngeal cancer risk in Caucasians (OR = 1.15, 95% CI = 1.01∼1.31), while no significant association was detected in Asians (OR = 1.25, 95% CI = 0.80∼1.96). In the subgroup analysis based on source of controls, significant associations were observed in the population-based studies (OR = 1.15, 95% CI = 1.01∼1.31) yet not in the hospital-based studies (OR = 1.25, 95% CI = 0.93∼1.67). Furthermore, in the subgroup analysis based on sample size, significant associations were also found in studies with at least 50 cases and 50 controls (OR = 1.15, 95% CI = 1.02∼1.30) but not in studies with fewer than 50 cases or 50 controls (OR = 1.46, 95% CI = 0.87∼2.46).ConclusionsThis meta-analysis supported that the GSTM1 gene polymorphism was associated with laryngeal cancer, particularly in Caucasians, and these associations varied in different subgroup, which indicated that population-based study with larger sample size was more appropriate in design of future study.

Dataset Information

Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.

Background

Methods

Results

Conclusions

Publications

Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.

Similar Datasets

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