Dataset Information

Bradykinin ?2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis.

ABSTRACT:

Background

Research has shown that bradykinin ?(2) receptor (BDKRB2) -58T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive.

Objective and methods

The objective of this study was to explore the association between BDKRB2-58T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2-58T/C gene polymorphism and EH and their corresponding 95% confidence intervals (CIs) were estimated using the random effects model.

Results

The BDKRB2-58T/C gene polymorphism was significantly correlated with EH under an allelic genetic model (OR?=?1.24, 95% CI?=?1.05-1.46; P?=?0.01), a dominant genetic model (OR?=?0.65, 95% CI?=?0.47-0.90; P?=?0.01), a recessive genetic model (OR?=?1.146, 95% CI?=?1.035-1.269; P?=?0.009), a homozygote genetic model (OR?=?1.134, 95% CI?=?1.048-1.228; P?=?0.002), and a heterozygote genetic model (OR?=?1.060, 95% CI?=?1.009-1.112; P?=?0.019).

Conclusions

The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH.

SUBMITTER: Li YY

PROVIDER: S-EPMC3416764 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

Bradykinin β2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis.

Li Yan-yan YY Zhang Hui H Xu Jian J Qian Yun Y Lu Xin-zheng XZ Yang Bing B Chen Minglong M Yang Zhi-jian ZJ Cao Ke-jiang KJ

PloS one 20120810 8

<h4>Background</h4>Research has shown that bradykinin β(2) receptor (BDKRB2) -58T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive.<h4>Objective and methods</h4>The objective of this study was to explore the association between BDKRB2-58T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2-58T/C gene polymorphism and EH and their c ...[more]

PMID: 22900090

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