Ontology highlight
ABSTRACT:
SUBMITTER: Klasse PJ
PROVIDER: S-EPMC3417324 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Cellular microbiology 20120605 8
Infection by HIV starts when the virus attaches to a susceptible cell. For viral replication to continue, the viral envelope must fuse with a cellular membrane, thereby delivering the viral core to the cytoplasm, where the RNA genome is reverse-transcribed. The key players in this entry by fusion are the envelope glycoprotein, on the viral side, and CD4 and a co-receptor, CCR5 or CXCR4, on the cellular side. Here, the interplay of these molecules is reviewed from cell-biological, structural, mec ...[more]