Ontology highlight
ABSTRACT:
SUBMITTER: Pollak DD
PROVIDER: S-EPMC3417703 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Pollak Daniela D DD Monje Francisco J FJ Zuckerman Lee L Denny Christine A CA Drew Michael R MR Kandel Eric R ER
Neuron 20081001 1
Although conditioned inhibition of fear (or learned safety) is a learning process critical for preventing chronic stress, a predisposing factor for depression and other psychopathologies, little is known about its functional purposes or molecular mechanisms. To obtain better insight into learned safety, we investigated its behavioral and molecular characteristics and found that it acts as a behavioral antidepressant in two animal models. Learned safety promotes the survival of newborn cells in t ...[more]