Ontology highlight
ABSTRACT:
SUBMITTER: Jackups R
PROVIDER: S-EPMC3417775 | biostudies-literature | 2010 Jul-Sep
REPOSITORIES: biostudies-literature
IEEE/ACM transactions on computational biology and bioinformatics 20100701 3
Motifs are overrepresented sequence or spatial patterns appearing in proteins. They often play important roles in maintaining protein stability and in facilitating protein function. When motifs are located in short sequence fragments, as in transmembrane domains that are only 6-20 residues in length, and when there is only very limited data, it is difficult to identify motifs. In this study, we introduce combinatorial models based on permutation for assessing statistically significant sequence a ...[more]